31 Mar Because all of our number 1 purpose, differences in the advantages of your own effects anywhere between male and female sex had been analysed
The newest endpoints Os, AFS, and you may liberty off amputation have been analysed using multivariable day-depending Cox regression habits in https://worldbrides.org/sv/latinwomendate-recension/ a complete model (the clients) along with sex-interaction words for every single chance basis. New activities to possess versatility off amputation noticed dying since a contending exposure compared to new AFS habits, which included demise on the endpoint. For this function, i used Great and you may Gray's way of guess sub-distributional hazard rates (HRs) regarding the AFS design.
The models included risk profiles of patients at baseline and additionally time-dependent occurrence of comorbidities or procedures in the follow-up period. Thus, we evaluated the interaction of sex with all variables in the Cox regression models. Two-sided P-values for the test of interaction of the two models were jointly adjusted using the Benjamini–Hochberg procedure 34 to control the false discovery rate (FDR) with respect to the multiple testing problem. False discovery rate-corrected P-values-denoted with P int-will be discussed and presented in the Supplementary material online. Additionally, we will quote the unadjusted two-sided interaction P-values for all models in the Supplementary material . All presented confidence intervals (CI) are standard unadjusted and all P-values relating to non-sex-interaction terms, i.e.